Q. The below case was diagnosed as osteosarcoma recently. Which of these genes is not associated in this condition as risk factor?
a. RECQL 4
b. RB 1
c. P 53
d. GNAS 1
Answer-
d
The above three genes have been associated with heritable syndromes leading to increased risk of osteosarcoma.
RB 1 - congenital bilateral retinoblastoma.
RECQL 4 - Rothmund- Thomson syndrome
p 53 - Li Fraumeni syndrome
GNAS 1 has been associated with McCune Albright syndrome with link to Fibrous dysplasia ( in association with precocious puberty)
a. RECQL 4
b. RB 1
c. P 53
d. GNAS 1
Answer-
d
The above three genes have been associated with heritable syndromes leading to increased risk of osteosarcoma.
RB 1 - congenital bilateral retinoblastoma.
RECQL 4 - Rothmund- Thomson syndrome
p 53 - Li Fraumeni syndrome
GNAS 1 has been associated with McCune Albright syndrome with link to Fibrous dysplasia ( in association with precocious puberty)
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